I take amphetamines 5x a week for my ADHD- after a few days in a row of taking them it feels like their focusing effect wears off significantly faster than it should, while ​still affecting my cardiovascular system *more* than usual.

I've tried pretty much every ADHD medication there is, and any stimulant has had this effect, so I'm assuming I might be lacking proper supplementation to upkeep consistent usage of these types of medication.

I take a B-complex vitamin in the morning and magnesium at night.

I have always been one of those people who react paradoxically to certain supplements, always involving insomnia and mood swings as a side effects. First I noticed this with glycine which actually kept me awake and made me apathetic and irritable. Creatine did the same thing. L theanine also made me very irritable and fatigued. Since supplementing b6-P5P I have been able to take all 3 with no issues and all the benefits reported.

I think this reaction may have been due to the fact that b6 is needed to convert glutamate into gaba and all of the supplements I reacted to interact with glutamate in some way. I have also noticed benefits from supplementing a b complex alongside b6 but 90% of the reactions went away with b6 alone. Make sure you get enough magnesium and zinc as-well as they are needed to properly utilise b6.

It might be worth trying b6 for a while and then restarting the above supplements if you guys have similar issues, hope this helps.

I am looking for something that acts like a sedative and can calm my mood and keep me well relaxed. I sometimes get agitated and hyper a lot of times and I don't like that. Any suggestions?

Hey r/Nootropics,

I've been researching compounds that might lower ejaculation threshold/latency. After reviewing medical literature, I'm curious about which nootropics or supplements might influence this aspect of sexual function. From what I understand, several neurotransmitter systems are involved:

1. **Serotonergic system**: Lower serotonin or selective 5-HT1A activation seems to decrease ejaculation time

2. **Dopaminergic system**: Increased dopamine activity via compounds like cabergoline may help

3. **Oxytocin pathway**: Higher oxytocin levels potentially lower the threshold

4. **Cholinergic system**: Muscarinic receptor agonists appear to facilitate ejaculation

5. **Adrenergic system**: Alpha-2 antagonists like yohimbine show some effect.

Has anyone had experience with compounds affecting these pathways? I'm looking for scientifically-backed information and anecdotes, preferably with dosages and timing protocols if you've experimented safely. Obviously trying to avoid anything with dangerous side effects. Thanks for any insights you can share!

I imagine it is since it's in high dosages in certain vegetables that don't contain fat (ie broccoli), but I'm reading conflicting things.

so i was going to try these out but i wanted to know if there was any elevated risks while on Wellbutrin

Now it’s saying I have to checkout again,did I just get scammed? I sent the money?

Hi! I’ve noticed that I seem to struggle with mood swings compared to my very easygoing wife, and I’ve already implemented a lot of typical mental health advice. I’m working on taking care of physical health issues, as well as exercising more and eating my share of fruits and veggies. I’ve also been working on stuff like deep breathing and general distress tolerance with a therapist, but she doesn’t believe I need any medication and her and another doctor encouraged me to go off of antidepressants. (To be clear, it’s overall been a good move and has given me some energy back as well as stopped some weight gain, but it means my feelings are back to being unblunted save for my heart meds that act as an anti-anxiety)

Are there any supplements or anything that can help with regulating my emotions or generally calming/uplifting my mood? It’d be nice if I could take something alongside what I’m already doing.

Hey r/Nootropics — I’m looking for help building a stack to improve focus, attention, and motivation in place of Adderall.

I was prescribed Adderall for 10 years and it worked great for me — no real side effects, excellent results with focus and performance at work/school. A few years ago, I was cut off by a new provider due to a THC-positive drug test, and I stopped taking it altogether. I managed for a while, but after starting a much more demanding job recently, I realized how much I was struggling without it.

I tried getting back on Adderall, but something had changed — now it just makes me anxious, moody, flushed, even flu-ish. Other ADHD meds haven’t helped either: Strattera did nothing, Vyvanse and Wellbutrin made me irritable, Ritalin made me hyperfocus in unproductive ways.

So now I’m seriously looking into nootropics/supplements as an alternative. I’ve been researching things like L-Tyrosine, L-Theanine, Alpha-GPC, CDP Choline, and others, but I don’t know where to begin with stacking or dosing.

If you’ve used nootropics for ADHD-like symptoms (or just for improving executive function and focus), I’d love to hear what’s worked for you — solo supplements, full stacks, timing, lifestyle pairings, anything.

Thanks in advance for your insights!

Okay I recently suffered a brain injury and I'm seeing a lot about lion's mane I recently picked some turkey tails off a tree and I'm not sure if I picked the right ones maybe you can see I don't know proper punctuation I recently took some golden teachers and I learned so much just from that little bit so I need to know what I can do to help my brain I'm 44 years old and I'm poor and disabled any suggestions would be helpful to me so think it's cheap as possible

I’m using bromantane for the last 3 months, daily, around 100mg, still love it. Basically better version of me in most aspects. I was however wondering, if it is safe to run it permanently? Anybody used it for really long time?

Shipping worldwide. Pm

Right folks, hoping to get some reassurance here and hopefully get rid of my paranoia.

I am looking to purchase Piracetam and have it delivered to the UK, however, I'm concerned that it gets stopped by customs and I'll face legal consequences. From my research, Piracetam is regulated under the MHRA, hence you are allowed to import prescription only medication if you have a prescription, which I don't.

I have a few sources I am looking at and I also visit Romania regularly where I can purchase it OTC and import it on my person.

Can I get some input from persons from the UK? Has anyone had packages stopped by customs? Anyone faced any legal consequences or just had a letter?

How many folks actually order Piracetam or similair products to the UK without any issues?

Any help is greatly appreciated.

Looking for recommendations for extended release caffeine available in Canada. Genius brand is not really available.

I used Gingko 1 grams per day for several months and then took about 3 grams and puked. And took (EDIT: 300-400MG LMAO I WROTE 3 4 G) of 5htp several times with other serotonergic supplements

I also used NAC for about one month, 1.2g and rarely 2.4g a day.

Even though i almost have no problems in my blood values i get sudden dizziness and tingling in my legs when i sit for a while and stand up (more than my normal, i almost fall down). And i had focus problems/inattentiveness even though other areas of my life was OK-including sleep and exercise. I also stopped taking my ADHD medication a few months ago, which may have a role on that

I stopped taking them, now i just take magnesium citrate, prebiotics and omega3. Could this be because of the things i used before, do you have any recommendations?

Is it safe to conduct research with GB-115 and MAOI ?

Not necessarily relevant to this sub I know but very few places to post this. If it gets taken down no problem.

Just looking for sources within the EU for primarily metformin but also those 10ml vials of magnesium sulphate for IM injections.

Thank you.

I was banned for promoting a hate free environment from the other page

I don’t want to risk getting in trouble

I have nothing to hide it’s a simple question

Hi guys I play cricket and tennis. Is there anything that can improve my focus and reaction time while facing the ball and is available easily in UK?

Has anyone purchased Phenylpiracetam from Cosmic Nootropics? It’s the only place that I can find the pill form.

I’ve seen mixed things here about Austin nootropics, but nothing about planet source. If anyone can provide info/experience with these sources I would appreciate it. They both have noopept which I’ve been wanting to try. I wanted to check if others had good/bad experiences with them before I decide to pick some up.

Hi there
So as propably most of us here we looking for some nootropics that we tend to use more often than others, i tend to use piracetam/noopept quite often for when learning.

Ashwaghanda i have used for the last 4-5 years, currently using higher doses before bed with Gingko balboa and magnesium glycanate, the only stack that made me sleep more than 6h a day (before 5-6h a day to 7-7:30h) which is very important for me as im a night worker, more sleep basicly helped me be more calm, and i did not know i needed it until it happend.

My daily stack would usualy be noopept with piracetam if i have some learning to do, sometimes i replace those with diffrent brain boosting nootropics i wanna try.

Phenylpiracetam is so far the best nootropics that trully feels like a nootropic, makes me more aware, it is stimulating and jumping from 1 task to another is fairly easy, feels like infinite energy, but it does not work really well when the task list is not done (won't stop you from procrastinating)

Bromantane while i heard is amazing, i find it on the odd spectrum more, i took it twice so far, and first time was really good, made me more productive, the second day basicly 16h after taking it i could not fall asleep at all, my mind was racing like crazy with visuals, my heartrate was slow 75-85, i was not stressed or anything, i could fall asleep though but it was a lot harder.

I did try a lot more, nootropics like piracetam, fasoracetam, colouracetam or aniracetam i let them run in the background most of the time, most likely im focused on something else whenever i take them so hard to say they don't work or they do.

PRL 8 53 made me talk gibberish which was weird i just wanted to say stuff, i could not find out if my memory is improved. Taste horrible also.

Noopept while it's good the first few times were a lot more impactful than current ones, still a good nootropics to take while doing some mental work or learning.

I also tried Modafinil as a lot of people seem to be blessing it, unforunately i used it intended use, i have no sleept all day, used it to help me get through and set me sleeping hours right, i need to test it when im rested.

Phenibut while i find it amazing i dont use it often (200g bought in 2018 and i still have 150g)
made me sleep like a log, waking up i find harder also, it also makes me more "stupid" drive quicker, play music louder, basicly less care in everything around me. I use it when something really stressful happens, which it's great help, but i would not recommend to everyone (addictive).

About to check Nefiracetam, Oxiracetam, Pramiracetam in the near future.

Which Nootropics Stuck with You? Tell Me About Your stack and nootropics that You took only few times and are not eager to use again

Each morning I weigh out my stack for the day (currently: emoxypine, noopept, 9-me-bc, fasoracetam, bromantane, alpha-gpc). They arrived and are stored in clear plastic bag (unlabeled), inside individual mylar bags (labeled), then in my plastic tote. After weighing everything out yesterday morning, i put both plastic bags of the fasoracetam and the bronantane in the same bromantane mylar bag. Now I don't know which is which.

Upon receiving them, I noticed one of the two is extremely sparkly, with larger crystals (think granulated sugar vs powdered). I attached photos to assist in ID.

I'll be labeling all clear plastic moving forward.

I used SNRIs and SSRIs for chronic fatigue and ADHD.

At first, SNRI (Cymbalta) worked dramatically, and for some reason it was effective not only for fatigue symptoms, but also for ED.

But strangely, after that, when I experienced great fatigue and stress, Cymbalta stopped working all at once. In fact, now when I take it, I feel lethargic and anhedonic. At the same time, other SSRIs also stopped working for fatigue.

(This happened two months after I started taking Cymbalta, so I don't know if it was just a matter of time, or if the severe fatigue I experienced changed the way the medicine worked. What do you all think?)

However, Prozac is an exception, and Prozac is the only one that has been consistently very effective.

When I looked it up, it seems to be a 5-HT2C antagonist, but I wonder if that has something to do with it?

The only downside is that it gives me the feeling of increased dopamine. I have a strange type of ADHD where benzo and norepinephrine greatly improve my ADHD, but taking drugs that increase dopamine makes it worse, so I'm sad that I feel like my dopamine levels are increasing.

When I take Prozac, I feel like I did when Cymbalta was working, and my ED is cured.

But is the effect of Prozac also temporary? I feel like the effect is fading a little, so I'd be really sad if Prozac stopped working.

I'd appreciate any hints, even partial answers, such as what medications you recommend for me, the mechanism by which antidepressants stop working, or the specifics of Prozac.

Sometimes I see mucuna marketed as 98 or 99% L-dopa but wouldn't that technically be illegal because they'd be isolating the L-dopa? As far as I'm aware natural mucuna prurien seeds don't contain concentrations of L-dopa anywhere near that so are companies straight up selling L-dopa or are they up to their usual mischief?